Cancer chemotherapy is the use of drugs to kill cancer cells. Unlike radiation and surgery, which are localized treatments, chemotherapy is a systemic treatment, meaning the drugs travel throughout the whole body. This means chemotherapy can reach cancer cells that may have spread, or metastasized, to other areas. It also means that the chemotherapy will affect normal cells in various parts of the body as well, producing side effects that may be unpleasant.
Chemotherapy for bladder cancer may be delivered by mouth, through the vein (intravenously), or instilled directly into the bladder (intravesical chemotherapy). Chemotherapy may be given alone, or in addition to other treatments, such as
Intravesical chemotherapy may be given to patients with superficial tumors that were removed through a
transurethral procedure. This form of chemotherapy can then be used to kill any cancer cells that may remain. Oral and IV chemotherapy for bladder cancer is usually given to patients with higher grade, more invasive cancers. Patients who already have metastatic cancer may also be offered chemotherapy.
Chemotherapy Drugs Used for Bladder Cancer
The following chemotherapeutic agents may be given to treat bladder cancer:
Chemotherapy drugs are often given in combinations. Your doctor will use information about your
tumor grade and cancer stage
to design an effective chemotherapy regimen for you.
Chemotherapy may be used for metastatic bladder cancer; while chemotherapy won’t cure metastatic disease, it may help increase survival time. Tumors that don’t respond to chemotherapy may have a worse prognosis.
Side Effects and Possible Complications
In addition to the side effects of chemotherapy in general, chemotherapy to treat bladder cancer may cause the following side effects:
Bladder irritation causing:
Frequent need to urinate
Urgent need to urinate
Pain and/or burning with urination
8th ed. New York, NY: Elsevier Science; 2002: 2732-2765.
Manual of Clinical Oncology.
5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004.
Please be aware that this information is provided to supplement the care
provided by your physician. It is neither intended nor implied to be a
substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER
IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the
advice of your physician or other qualified health provider prior to
starting any new treatment or with any questions you may have regarding a