Conditions InDepth: Rheumatoid Arthritis
Rheumatoid arthritis is a chronic disease that causes inflammation in the joints and certain other organs throughout the body. It is called an autoimmune disorder. It is believed that the body’s immune system accidentally mistakes its own tissues for foreign invaders. The immune system attacks the joints and organs, causing damage.
Researchers aren’t sure what causes the immune system to respond so destructively. It may be caused by a combination of factors, including:
- Genes—People with rheumatoid arthritis may have a specific genetic defect that increases their risk for developing this condition.
- Defects in the immune system may cause the immune cells to fail to recognize the body’s own tissues.
- Infection with specific viruses or bacteria that kick off an abnormal immune response.
- Chemical or hormonal imbalances in the body.
More than two million Americans (about 1% of the total population) have rheumatoid arthritis.
Arthritis Foundation website. Available at: http://www.arthritis.org/ .
National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: http://www.niams.nih.gov/ .
Cecil Textbook of Medicine . 21st ed. W.B. Saunders Company; 2000.
Conn’s Current Therapy . 54th ed. W.B. Saunders Company; 2002.
Last reviewed September 2009 by
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