I had a radical hysterectomy in 2006 at the age of 50. I tried wearing a HRT patch, which I was told would have the least side effects of any HRT. I became a witch from hell, and gained 30 lbs. almost over night. I worked with a pharmacist, and used cream that he created and it did not work either. One year ago I found Amberen! It has been a life saver. It took care of the hot flashes, night sweats, mood swings and I have even been able to lose some weight.