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NET's - The Second Most Prevalent Malignant Tumor

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Gastrointestinal neuroendocrine tumors (NETs) are the second most prevalent malignant type of gastrointestinal tumor in the U.S.. It is estimated that over 100,000 Americans are affected (1). NETs grow more slowly than other cancers of the GI tract. Once considered rare, the incidence of gastrointestinal neuroendocrine tumors is increasing. Early diagnosis, intervention, and control of symptoms are essential.

The gastrointestinal tract contains more neuroendocrine cells than any other system in the body. Neuroendocrine cells have the characteristics of nerve cells and hormone-prducing cells. In the GI tract, neurendocrine cells control the release of digestive juices and the rate at which food passes through (2).

Gastrointestinal neuroendocrine tumors are classified as pancreatic neuroendocrine tumors and carcinoid tumors.

Pancreatic neuroendocrine tumors originate within the pancreas and account for 5 percent of all pancreatic tumors. Pancreatic NETs are classified according to the hormone producing cell of origin. Half are identified as functioning because the tumor produces hormones, The remaining are classified as non-functioning because the tumor does not produce hormones.

Carcinoid refers to neuroendocrine tumors which develop in the stomach, intestines, appendix and rectum. It is the more common type of gastrointestinal neuroendocrine tumor. NETs secrete a variety of hormones. In most cases, the levels of hormones secreted by the tumor are not significant enough to produce symptoms. However, as the tumor grows and spreads, high amounts of hormones are released. About one in 10 individuals with carcinoid tumors will experience carcinoid syndrome. Symptoms of carcinoid syndrome are redness of the skin with a feeling of warmth, diarrhea, and a rapid heart rate (3).

Gastrointestinal neuroendocrine tumors are more common among Afro-Americans and women. Some individuals with a family history of neurofibromatosis type one develop NETs of the small intestines. It is estimated that inherited mutations of the MEN1 gene account for 10 percent of carcinoid tumors (2).

Diagnosis is made by biochemical monitoring and radiological imaging. Blood tests measure the levels of substances released by the tumor. CT imaging and MRI are used to identify the location of the tumor

The first goal of treatment is reduction and removal of the tumor. Chemotherapy, use of biological agents, such as somatostatin and interferon-alfa, and hormone therapy are medical interventions against NETs. The treatment is dependent upon the location and extent of the tumor (4).

(1) www.medscape.com
(2) www.cancer.org
(3) www.cornellsurgery.org
(4) www.mskcc.org

Maryann Gromisch is a registered nurse with clinical experience in medical, surgical, and critical care nursing. She has experience assisting a gastroenterologist in a private practice setting.

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EmpowHER Guest

Thenetalliance.com is a great patient comminty for NETs sufferers.

November 15, 2010 - 9:16am
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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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