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Hormonal therapy medications are whole-body (systemic) treatment for hormone-receptor-positive breast cancers. When hormone receptors in the breast get signals from hormones, cell growth increases. And since the more hormones there are in the body (particularly estrogen and progesterone), the more cancer cells will grow. So the point would be to decrease the hormone growth systemically.
Therefore, hormonal therapy medicines are used to:
Decrease the chances of early-stage hormone-receptor-positive breast cancer recurring
Decrease the chances of hormone-receptor-positive breast cancer in women who are at high risk but cancer-free at the present
Help shrink or slow the growth of advance-stage or metastatic hormone-receptor-positive breast cancers
Hormonal therapy medications can be used in treatment instead of ovarian shutdown or removal. With ovarian shutdown, the ovaries are surgically removed as a risk-reduction measure in treating hormone-receptive-positive breast cancer. This will permanently stop estrogen from being produced. While some appreciate this fact, others may choose medications for personal reasons of their own.
What it is Not
Please be aware that hormonal therapy is not hormone replacement therapy (HRT). Hormonal therapy, as stated previously, is used to decrease the hormone level in the body and HRT is used to increase it. Hormonal therapy is used in regards to hormone-receptor-positive breast cancer while HRT is used to treat symptoms of menopause. It is considered very unsafe to use HRT if a patient is diagnosed with this type of cancer.
Types of Hormonal Therapy Medicines
There are three types of hormonal therapy medicines:
Estrogen-receptor downregulators (ERDs)
Selective estrogen receptor modulators (SERMs)
Aromatase inhibitors act as a barrier to the enzyme aromatase, which ultimately means less estrogen to simulate any breast cancers. Side effects for this drug may be heart problems, bone loss, joint stiffness or joint pain.
ERDs neutralize the effect of estrogen in breast tissue.