How does Lupus affect the brain?

To answer your question,  I went to the website of the Lupus Foundation of America.

Though the nervous system involvement in systemic lupus erythematosus (SLE) is unclear and controversial, people with lupus do often experience signs associated with the body's nervous system, such as: headaches, confusion, difficulty with concentration, fatigue and occasional seizures or strokes.

The nervous system collectively  includes the brain, spinal cord, the peripheral nervous system (the nerves that supply the skin and muscles) and the autonomic nervous system.

One of the most serious forms of systemic lupus is central nervous system vasculitis

To learn more about lupus and the nervous system,

http://www.lupus.org/webmodules/webarticlesnet/templates/new_donate.aspx?articleid=102&zoneid=6

Maryann