Methylnaltrexone

U.S. Brand Names

Relistor™

Pharmacologic Category

Gastrointestinal Agent, Miscellaneous; Opioid Antagonist, Peripherally-Acting

Reasons not to take this medicine

• If you have an allergy to methylnaltrexone or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have an intestinal blockage.

What is this medicine used for?

• This medicine is used to treat severe constipation caused by certain medicines.

How does it work?

• Methylnaltrexone increases gastric emptying and movement through the gastrointestinal tract.

How is it best taken?

• This medicine is given as a shot into the fatty part of the skin.

• Your healthcare provider may teach you how to give the shot.

• Wash hands before and after use.

• Move site where you give the shot with each shot.

• Throw away needles in needle/sharp disposal box and return box to healthcare provider when full.

What do I do if I miss a dose? (does not apply to patients in the hospital)

• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

• Do not take more often than every 24 hours, unless instructed by healthcare provider.

What are the precautions when taking this medicine?

• If you have kidney disease, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines. Combinations could be life-threatening.

• Tell healthcare provider if you are pregnant or plan on getting pregnant.

• Tell healthcare provider if you are breast-feeding.

What are some possible side effects of this medicine?

• Belly pain.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Gas.

What should I monitor?

• Change in condition being treated. Is it better, worse, or about the same?

• Follow up with healthcare provider.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Severe diarrhea.

• Any rash.

• No improvement in condition or feeling worse.

How should I store this medicine?

• Store at room temperature. Do not freeze.

• Protect from light.

General statements

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.



Created: 2008-05-09 13:10:42.0

Modified: 2008-05-09 15:08:45.0

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