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Is There a Link Between SSRIs and Ovarian Cancer? An Editorial

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Selective serotonin reuptake inhibitors (SSRIs) are excellent drugs and give hope to many people with a wide variety of mental health disorders. However, a recent study from Boston suggested that there is a link between ovarian cancer and use of these medications.

The research was done by Lisa Cosgrove, PhD, from Edmond J. Safra Center for Ethics, Harvard University in Boston, Mass., who used meta analysis to look at 61 studies. In their study, Cosgrove and her colleagues observed that there was a small but significant increase in risk of ovarian cancer in women who took SSRIs. The study provided a hint that perhaps the SSRIs were acting either as a tumor promoter or a cancer-causing agent.

The researchers observed that depressed women who were on SSRIs were slightly more likely to have developed some type of gynecological cancer. Another interesting finding, which has also been in the news lately, is that when doctors and researchers were affiliated with the pharmaceutical companies, the results were less likely to show any such correlation. (1) Whereas when doctors without affiliations evaluated the data, the correlation was more obvious between the drugs and cancer. However, it should be mentioned that one of the largest epidemiological studies (Dalton et al, Epidemiology. 2000;11:171-176) involving more than 39,000 people did not show any association between anti- depressant use and cancer.


Dr Jennifer Payne, MD, Director of the Women’s Mood Disorders Center at Johns Hopkins School of Medicine, Baltimore, MD., believes that publishing such data may have a negative effect on women who have depression, who may choose not to seek any anti-depressant therapy. So for now the issue of whether the SSRI increase risk of cancer is still a mystery. The question remains, whom does one believe?

There is no question, in my opinion, that doctors associated with pharmaceutical companies tend to minimize complications or tend not to report adverse side effects of drugs. However, in this case the one factor that mitigates that SSRIs may not be inducing cancer is that after 20 years, SSRIs have been prescribed to millions of people all over the world, and yet the incidence of ovarian cancer has remained stable.


Sources:
1. Drug firms wine, dine and pay up for doctors' speeches
http://www.jsonline.com/features/health/37421114.html

2. Possible Link Between SSRIs and Breast, Ovarian Cancer
http://www.medscape.com/viewarticle/740875

3. Ashbury JE, Lévesque LE, Beck PA, Aronson KJ. A population-based case-control study of Selective Serotonin Reuptake Inhibitors (SSRIs) and breast cancer: the impact of duration of use, cumulative dose and latency.BMC Med. 2010 Dec 22;8:90
http://www.ncbi.nlm.nih.gov/pubmed/21176215

Chien C, Li CI, Heckbert SR, Malone KE, Boudreau DM, Daling JR. Antidepressant use and breast cancer risk. Breast Cancer Res Treat. 2006 Jan;95(2):131-40
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720762/

Reviewed June 13, 2011
Edited by Alison Stanton

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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.